Population
Intact calf Purkinje fibers and isolated myocytes from guinea pig and rat ventricles
Design
Preclinical
Authors
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May explain divalent ion-DHP antagonism via surface potential; leaves open relevance to intact mammalian channels.
Divalent ion-induced changes in surface potential can account for most of the antagonism between these ions and calcium channel block by 1,4-dihydropyridines.
Kass et al. (1987) studied this question.
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