Key result
A low-dose combination of fluvastatin and valsartan administered intermittently improved arterial wall characteristics and decreased arterial age after one month of treatment.
Why the study?
Does a low-dose combination of fluvastatin and valsartan improve arterial wall characteristics and decrease arterial age?
Does a low-dose combination of fluvastatin and valsartan improve arterial wall characteristics and decrease arterial age?
A novel intermittent low-dose combination of fluvastatin and valsartan is proposed as a potential approach to decrease arterial age.
Should not change practice for arterial stiffness; hypothesis-generating and leaves open efficacy in randomized trials.
We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achieved after a short period of treatment (one month) with the above-mentioned drugs. In addition, we have also implemented a new, innovative therapeutic approach, consisting of intermittent (cyclic) treatment-alternating short "treatment" periods and much longer "rest" periods (when the beneficial effects are still present but gradually decline). This new "drug" and approach both merit further investigation in order to confirm their antiaging efficacy.
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Janić et al. (2015) studied Increased arterial age. Low-dose combination of fluvastatin and valsartan was evaluated on Arterial age and arterial wall characteristics. A low-dose combination of fluvastatin and valsartan administered intermittently improved arterial wall characteristics and decreased arterial age after one month of treatment.
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