A bumper crop of “polyunsaturated” cyclophanes has recently been harvested as a result of methodological advances, which have once again fertilized the field of cyclophane chemistry. Features of these designed molecules include structural novelty, strain and its consequences, unusual electronic effects, exploitable physical properties, and stereochemistry. Otera's “enantiopure double-helical alkynyl cyclophanes” (example shown in picture) are perhaps the pick of the crop.
No takes yet. Share an insight, caveat, or question.
A 2002 study studied this question.