Smears of synovial fluid specimens from 7 of 10 selected patients were found to contain lupus erythematosus (LE) cells. In 1 patient, LE cells were found in smears of synovial fluid but not of blood. Direct smears of synovial fluid immediately after aspiration from 2 patients contained LE cells, thus suggesting that in vivo these cells form in synovial fluid.
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Hunder et al. (1970) studied this question.
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