Hyperaldosteronism and Hypergranularity of the Juxtaglomerular Cells in Renal Hypertension

Article1 July 1963Hyperaldosteronism and Hypergranularity of the Juxtaglomerular Cells in Renal HypertensionMetabolic StudiesMARTIN GOLDBERG, M.D., DONNA K. MCCURDY, M.D.MARTIN GOLDBERG, M.D.Search for more papers by this author, DONNA K. MCCURDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-24 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past few years a series of important investigations has indicated that the kidney plays a key role in the regulatory mechanisms controlling the secretion of aldosterone by the adrenal gland (1-6). Procedures that reduce blood flow or perfusion pressure to the kidney, such as hemorrhage (2, 7), renal artery (4) or suprarenal aortic constriction (6), and sodium depletion (3) cause an increased secretion of aldosterone. The aldosterone hypersecretion in response to hemorrhage and sodium depletion can be prevented by bilateral nephrectomy (2, 3). It has also been demonstrated in animals that the granularity of the juxtaglomerular (JG) cells...References1. TOBIAN L: Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol. Rev. 40: 280, 1960. CrossrefMedlineGoogle Scholar2. DAVISCARPENTERAYERSHOLMANBAHN JOCCCRJERC: Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J. Clin. Invest. 40: 684, 1961. CrossrefMedlineGoogle Scholar3. DAVISAYERSCARPENTER JOCRCC: Renal origin of an aldosterone-stimulating hormone in dogs with thoracic caval constriction and in sodium-depleted dogs. Ibid., 1466. Google Scholar4. CARPENTERDAVISAYERS CCJOCR: Relation of renin, angiotensin II, and experimental renal hypertension to aldosterone secretion. Ibid., 2026. Google Scholar5. MULROWGANONGCERAKULJIAN PJWFGA: The nature of the aldosteronestimulating factor in dog kidneys. J. 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WOLF AV: Osmometric analysis of thirst in man and dog. Amer. J. Physiol. 161: 75, 1950. CrossrefMedlineGoogle Scholar28. ELKINTON JR: Hyponatremia: clinical state or biochemical sign? Circulation 14: 1027, 1956. CrossrefMedlineGoogle Scholar29. LARAGHULICKJANUSZEWICZDEMINGKELLYLIEBERMAN JHSVQBWGS: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest. 39: 1091, 1960. CrossrefMedlineGoogle Scholar30. BIGLIERIFORSHAM EGPH: Studies on the expanded extracellular fluid and responses to various stimuli in primary aldosteronism. Amer. J. Med. 30: 564, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Chemical Section, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 4, Pennsylvania.Dr. Goldberg is a Research Career Development Awardee of the National Institute of Arthritis and Metabolic Disease, National Institutes of Health (Grant No. AMK3 18582). These studies were aided by United States Public Health Service grants H 7284, HE 00340 14, 8M01 FR 40-03, and the C. Mahlon Kline fund for the development of the Department of Medicine.Requests for reprints should be addressed to Martin Goldberg, M.D., 860 Gates Pavilion, Hospital of the University of Pennsylvania, Philadelphia 4, Pennsylvania. 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BLAKEMORE, M.D., F.A.C.S. 1 July 1963Volume 59, Issue 1_Part_1Page: 24-36KeywordsAldosteroneCareers in researchCellsHemorrhageHospital medicineHypertensionIngestionKidneysSodiumSurgery Issue Published: 1 July 1963 PDF downloadLoading ...