Key result
In the anesthetized ferret, ET-1 and big ET-1 elicited dose-dependent pressor responses without preceding vasodilation, while ET-3 and S6c elicited transient vasodilation preceding the pressor response.
Population
Anesthetized ferrets
Design
Preclinical
Authors
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No immediate clinical translation from ferret data; leaves open ET(B) subtype roles pending human studies.
The anesthetized ferret provides a suitable nonrodent model for assessing endothelin potencies and supports the existence of ET(B) receptor subtypes.
Krause et al. (1999) studied this question. Endothelin agonists and antagonists was evaluated on Pressor and vasodilatory responses. In the anesthetized ferret, ET-1 and big ET-1 elicited dose-dependent pressor responses without preceding vasodilation, while ET-3 and S6c elicited transient vasodilation preceding the pressor response.
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