Summary: The appearance and distribution of γ-glutamyl transpetidase(γ-GTP)in the proliferative state of the liver were investigated by the methods of enzyme histochemistry and immunohistochemistry with monoclonal antibodies which specifically react with a heavy subunit of γ-GTP. In the fatal and neontal liver, a positive reaction was observed along the luminal border of the interlobular bile ducts and that of the bile canaliculi in zones 1 and 2of Rappaport. On the other hand, after partial hepatectomy, γ-GTP was localized along the luminal border of the interlobular bile ducts and that of the bile canaliculi in zone 1 of Rappaport. Both the enzyme histochemical and immunohistochemical methods yielded almost the same results for the distribution of γ-GTP.
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Shiozawa et al. (1986) studied this question.