Key result
A family history of VTE was the strongest independent predictor of pregnancy-associated venous thromboembolism, increasing the odds by over 50-fold (OR 50.47).
Why the study?
Venous thromboembolism is the most common cause of morbidity and death during pregnancy and the postpartum period, but its predictors needed description.
Case-Control (n=380)
No
Answers are grounded in this paper and cite their sources.
Family history, thrombophilia, and gross varicose veins are strong independent predictors of pregnancy-associated venous thromboembolism, suggesting a need for targeted prophylaxis in high-risk women.
Background Venous thromboembolism (VTE), manifesting as pulmonary embolism (PE) or deep vein thrombosis (DVT), is the most common cause of morbidity and death during pregnancy and the postpartum period. We conducted this study to describe the predictors of pregnancy-associated VTE (DVT and PE). Methods A case-control study was conducted at a tertiary care center in Riyadh. A total of 380 patients were included in this study, 180 of whom were diagnosed with pregnancy-associated thrombosis and 200 of them showed no VTE. Demographic data and data on risk factors of VTE were collected by reviewing the medical charts and the risk assessment tool of the Royal College of Obstetricians and Gynecologists, respectively. The main outcome measures were VTE, manifesting as PE or DVT. Results The following factors were identified as the predictors of VTE through multivariate analysis: family history [Odds ratio (OR) = 50.47, 95% Confidence Interval (CI): 6.78–375.64, P < 0.0001)], thrombophilia (OR = 21.99, 95% CI: 2.83–170.63, P = 0.003), and presence of gross varicose veins (OR = 17.15, 95% CI: 3.93–74.87, P < 0.0001). Conclusions The findings of this study showed that family history, thrombophilia, and the presence of gross varicose veins were risk factors for VTE, exceeding other transient risk factors. Hence, prophylaxis is highly recommended for those women who present with any of these factors.
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AlSheef et al. (2022) conducted a case-control in Pregnancy-associated venous thromboembolism (n=380). Family history of VTE vs. No family history of VTE was evaluated on Pregnancy-associated venous thromboembolism (OR 50.47, 95% CI 6.78-375.64, p=<0.0001). A family history of VTE was the strongest independent predictor of pregnancy-associated venous thromboembolism, increasing the odds by over 50-fold (OR 50.47).
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