Population
Rats on normal and low sodium diets
Comparison
Cicletanine and/or atrial natriuretic factor vs Normal sodium diet vs low sodium diet, and…
Design
Preclinical
Authors
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Hypothesis-generating for cicletanine in renal sodium handling; leaves open translation to human disease.
Cicletanine restores the glomerular response to atrial natriuretic factor in rats on a low sodium diet, likely via inhibition of cyclic GMP phosphodiesterase.
Kalinowski et al. (1997) studied this question.
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