The central event of the cell cycle is the orderly segregation of chromosomes at mitosis. Although chromosome segregation has been observed for more than 100 years, the detailed mechanism of movement remains obscure. Even less clear is the manner by which cell cycle regulatory information is made manifest in the specific events of chromosome segregation. One of the most fruitful approaches to the dissection of the cell cycle has been the isolation and characterization of cell cycle mutations in the unicellular fungi, Saccharomyces cerevisiae and Schizosaccharomyces pombe. Intensive analysis of key regulatory genes has helped reveal the universal nature of eukaryotic cell cycle regulation. Similar genetic analysis of chromosome segregation and other microtubule-dependent movements in yeast should provide insight into the fundamental mechanisms of mitosis.
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Roof et al. (1991) studied this question.