Key result
This review discusses various animal models, including zebrafish, rabbits, mice, and rats, and the methods used to study diabetic nephropathy.
Why the study?
Diabetic nephropathy is the most common complication of diabetes mellitus, causing substantial morbidity and mortality, prompting a review of animal models for Type 1 and Type 2 diabetes.
This review summarizes various animal models and methods used to study diabetic nephropathy.
Animal models aid diabetic nephropathy research but lack direct clinical applicability; leaves open identification of superior translational models.
Diabetic nephropathy (DN) is the most common complication of diabetes mellitus (DM). It is characterized by high blood glucose levels or hyperglycemia and is accompanied by changes in lipid, carbohydrate, and protein metabolism which can lead to an increased risk of complications due to vascular disease. DN is probably the most insidious among these complications, causing substantial morbidity and mortality. In this article, we will review the literature on animal models of diabetes. We will discuss several species as animal models for Type 1 and 2 diabetes, including zebrafish, rabbits, mice, rats, and rat models. This article also provides various methods used in research with model animals and presents the required result for studying diabetic DN.
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Azizah et al. (2023) conducted a review in Diabetic nephropathy. Animal models of diabetes was evaluated. This review discusses various animal models, including zebrafish, rabbits, mice, and rats, and the methods used to study diabetic nephropathy.
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