Key result
Chronic treatment with direct thrombin inhibitors reduced atrial remodeling and the duration of atrial fibrillation episodes induced by burst pacing in a rat model of heart failure.
Why the study?
Do direct thrombin inhibitors prevent left atrial remodeling and reduce AF duration in a rat model of heart failure?
Population
Rat model of heart failure associated with left atrial dilation
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether direct thrombin inhibitors attenuate atrial remodeling in human HF.
Do direct thrombin inhibitors prevent left atrial remodeling and reduce AF duration in a rat model of heart failure?
In a rat model of heart failure, direct thrombin inhibitors reduced atrial remodeling and AF duration, suggesting a potential role in slowing arrhythmogenic substrate progression.
Jumeau et al. (2016) studied Heart failure associated with left atrial dilation. Direct thrombin inhibitors (DTIs) was evaluated on Left atrial remodeling and duration of atrial fibrillation (AF) episodes induced by burst pacing. Chronic treatment with direct thrombin inhibitors reduced atrial remodeling and the duration of atrial fibrillation episodes induced by burst pacing in a rat model of heart failure.
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