What question did this study set out to answer?

To determine whether local cortisol production and mineralocorticoid or glucocorticoid receptor activation occur within the carotid arterial wall and contribute to atherosclerotic remodeling and stroke.

July 20, 2012Fundamental and Clinical Pharmacology

Auto‐amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke

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Authors

HAHanène AyariCHU Dijon Bourgogne LLLiliana LegedzUniversité Claude Bernard Lyon 1 PLPierre LantelmeHôpital de la Croix-Rousse

Discussion

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Implication

Translational study reveals local cortisol auto-amplification in human carotid atheroma, indicating that vascular steroid signaling promotes arterial remodeling and stroke risk.

Key Points

To determine whether local cortisol production and mineralocorticoid or glucocorticoid receptor activation occur within the carotid arterial wall and contribute to atherosclerotic remodeling and stroke.
Evaluated gene expression of corticoid system components and atheroma markers in human carotid atheroma plaques and adjacent macroscopically intact tissue (MIT) alongside clinical history.
Treated cultured human vascular smooth muscle cells (VSMCs) in contractile and lipid-storing phenotypes with cortisol, cortisone, and fludrocortisone to assess phenotypic responses.
Carotid atheroma plaques and lipid-storing VSMCs expressed two- to tenfold higher levels of 11β-HSD1 than MIT or contractile VSMCs, with expression further stimulated by cortisol and cortisone.
Cortisol upregulated collagen1 and MCP-1 expression via the glucocorticoid receptor (GRα) in both VSMC phenotypes, whereas mineralocorticoid receptor expression was downregulated in atheroma tissue.
Parietal GRα mRNA levels in intact tissue were higher in patients with prior stroke and correlated positively with collagen1 mRNA but negatively with diastolic blood pressure.

Cite This Study

Ayari et al. (2012) studied this question.

synapsesocial.com/papers/6a83188772cfe61ae898f992 https://doi.org/10.1111/j.1472-8206.2012.01064.x

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Implication

Translational study reveals local cortisol auto-amplification in human carotid atheroma, indicating that vascular steroid signaling promotes arterial remodeling and stroke risk.

Auto‐amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Auto‐amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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