Key result
Five unrelated families were identified with a novel autosomal dominant cardiac syndrome characterized by persistent, nonischemic ST-segment depression, atrial fibrillation, and ventricular arrhythmias.
Describes a novel autosomal dominant familial cardiac arrhythmia syndrome characterized by widespread ST-segment depression.
May prompt family screening in unexplained cases; hypothesis-generating and should not change practice pending validation.
To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to represent a previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac disorders (as described in the Supplementary Appendix, available with the full text of this letter at NEJM.org)
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Bundgaard et al. (2018) conducted a letter in Familial Cardiac Arrhythmia Syndrome (n=23). Novel familial cardiac arrhythmia syndrome was evaluated on Clinical and electrocardiographic characterization of the syndrome. Five unrelated families were identified with a novel autosomal dominant cardiac syndrome characterized by persistent, nonischemic ST-segment depression, atrial fibrillation, and ventricular arrhythmias.
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