Carboxylic acids 1 and 7 reacted effectively with unprotected α-amino acids 2 containing another hydrophilic moiety under basic conditions via activation by ethyl chloroformate and triethylamine to afford the corresponding amides in 74–99% yields.
No takes yet. Share an insight, caveat, or question.
Noguchi et al. (2012) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: