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An active‐site water molecule coordinated by conserved histidine and asparagine residues seems to serve as the catalytic base in all ent ‐copalyl diphosphate synthases (CPSs). When these residues are substituted by alanine, the mutant CPSs produce stereochemically novel ent ‐8‐hydroxy‐CPP. Given the requisite presence of CPSs in all land plants for gibberellin phytohormone biosynthesis, such plasticity presumably underlies the observed extensive diversification of the resulting labdane‐related diterpenoids.
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Potter et al. (2014) studied this question.
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