Biochemical study reveals optical detection of telomerase activity using catalytic hemin–G-quadruplex DNAzymes, indicating a simpler method to screen anticancer enzyme inhibitors.
An escape from the TRAP: Telomere chains self-assemble into catalytically active hemin–G-quadruplex units. We describe how the resulting DNAzyme units can be used for quantitative analysis of telomerase activity and its inhibitors.
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Freeman et al. (2010) studied this question.
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