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April 9, 2010European Journal of PediatricsOpen Access

Distinctive clinical features of human bocavirus in children younger than 2 years

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Why the study?

Does human bocavirus infection present with different clinical features compared to RSV infection in children under 2 years with LRTI?

Population

402 hospitalized children younger than 2 years with lower respiratory tract infection (LRTI) in Japan.

Comparison

Human bocavirus (HBoV) single infection (n=18) vs Respiratory syncytial virus single infection

Design

Cohort

Follow-up

Hospital stay (mean 6.6 days for HBoV)

Authors

YMYoko MoriyamaHHHiromichi HamadaMOMineyuki Okada

Discussion

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Overview

Human bocavirus infection in young children with lower respiratory tract infection presents with distinct clinical features, including more severe hypoxia and higher neutrophilia, compared to respiratory syncytial virus infection.

Structured PICO

Does human bocavirus infection present with different clinical features compared to RSV infection in children under 2 years with LRTI?

P
Population
402 hospitalized children younger than 2 years with lower respiratory tract infection (LRTI) in Japan.
I
Intervention
Human bocavirus (HBoV) single infection (n=18)
C
Comparator
Respiratory syncytial virus (RSV) single infection (n=99)
O
Outcome
Clinical and laboratory characteristics (including oxygen saturation, white blood cell counts, and neutrophil percentage)

Human bocavirus infection in young children with lower respiratory tract infection presents with distinct clinical features, including more severe hypoxia and higher neutrophilia, compared to respiratory syncytial virus infection.

Limitations

  • Small sample size for HBoV-positive cases
  • Did not survey all respiratory viruses such as coronavirus or influenza virus
  • Lack of quantification of viral loads

Cite This Study

Moriyama et al. (2010) studied this question.

synapsesocial.com/papers/6a832a7495f6f1aefa9c9503https://doi.org/10.1007/s00431-010-1183-x
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