Beyond telomeric G-quadruplexes: remarkable binding of PhenQE8 to promoter sequences

Lachhman Singh; Sachin Metangle; Ratnesh Tiwari; Nihar Ranjan

doi:10.1039/d4nj02016b

December 10, 2024New Journal of Chemistry

Beyond telomeric G-quadruplexes: remarkable binding of PhenQE8 to promoter sequences

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Key Points

Investigate the binding properties of the ligand PhenQE8 toward promoter G-quadruplex DNA structures beyond classical telomeric sequences.
Assessed the interaction and binding specificity of the small molecule PhenQE8 against promoter G-quadruplex motifs.
PhenQE8 displays strong binding affinity for non-telomeric promoter G-quadruplex sequences.
Targeting promoter G-quadruplex structures provides a viable mechanistic strategy for therapeutic cancer intervention.

Implication

In vitro analysis demonstrates targeting of promoter G-quadruplexes by PhenQE8, highlighting novel strategies against tumor growth.

Abstract

Due to their key roles in tumor growth and carcinogenesis, G-quadruplexes have been established as potential drug targets for the treatment of cancer. The small molecules that are capable to...

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Cite This Study

Singh et al. (2024) studied this question.

synapsesocial.com/papers/6a8331bd191215dee0b3871b https://doi.org/10.1039/d4nj02016b

View at Publisher

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Beyond telomeric G-quadruplexes: remarkable binding of PhenQE8 to promoter sequences

Key Points

Implication

Abstract

Discussion

Cite This Study

Beyond telomeric G-quadruplexes: remarkable binding of PhenQE8 to promoter sequences

Key Points

Implication

Abstract

Discussion

Cite This Study

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