Why the study?
Management of analgesia and hemodynamic status is essential for orthopedic surgery patients, motivating evaluation of intrathecal bupivacaine or pethidine with or without magnesium sulfate.
Does the addition of magnesium sulfate to intrathecal bupivacaine or pethidine affect hemodynamic status and block duration in patients undergoing orthopedic surgery?
Does the addition of magnesium sulfate to intrathecal bupivacaine or pethidine affect hemodynamic status and block duration in patients undergoing orthopedic surgery?
Intrathecal magnesium sulfate added to pethidine prolongs sensory block duration without adverse hemodynamic effects, whereas it reduces block duration when added to bupivacaine.
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Magnesium as spinal adjuvant warrants drug-specific selection to avoid shortening block with bupivacaine; extends interaction data from this RCT.
MojaverAghili et al. (2022) studied this question.
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