One gram each of FCE 22101 and its acetoxymethyl ester (FCE 22891) were administered sequentially to six healthy volunteers. After intravenous administration Cmax was 167 mg/l, and the elimination half-life 0.8 h. Following oral administration Cmax was 6.9 mg/l and the elimination half-life 0.6 h. Penetration into inflammatory fluid was rapid, and the percentage penetration 86.1 and 60.9% following oral and intravenous dosing respectively. Urine recovery was greater after intravenous administration (31%) than after oral (11%).
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Webberley et al. (1988) studied this question.