SCARB2, one of the receptors for enterovirus A71, is not expressed on the cell surface.

Yorihiro Nishimura

doi:10.2222/jsv.74.153

January 1, 2024UirusuOpen Access

SCARB2, one of the receptors for enterovirus A71, is not expressed on the cell surface.

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Structured PICO

P

Population

Human cell lines including Jurkat (human lymphocyte), RD (human rhabdomyosarcoma), 293T, HeLa, Hep G2, and HEp-2 cells.

I

Intervention

SCARB2 knockout, PSGL-1 knockout, SCARB2 overexpression, and anti-SCARB2 antibody treatment.

C

Comparator

Wild-type cells, empty vector transfection, or control antibody treatment.

O

Outcome

Cell surface expression of SCARB2, EV-A71 adsorption/binding, and EV-A71 infection efficiency.surrogate

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Implication

This study refutes the 15-year-old dogma that SCARB2 is a cell surface receptor for EV-A71, demonstrating instead that it functions exclusively intracellularly to induce viral uncoating.

Abstract

PSGL-1 Jurkat

Discussion

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Cite This Study

Yorihiro Nishimura (2024) studied this question.

synapsesocial.com/papers/6a83348a817bd1e6059c9604 https://doi.org/10.2222/jsv.74.153

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SCARB2, one of the receptors for enterovirus A71, is not expressed on the cell surface.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

SCARB2, one of the receptors for enterovirus A71, is not expressed on the cell surface.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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