Why the study?
Familial hypertrophic cardiomyopathy is a leading cause of sudden cardiac death in young individuals, but the association between late potentials and prognostic markers like family history of sudden death, syncope, and complex ventricular arrhythmias required investigation.
Does the presence of late potentials correlate with familial sudden death, syncope, and complex ventricular arrhythmias in patients with hypertrophic cardiomyopathy?
Does the presence of late potentials correlate with familial sudden death, syncope, and complex ventricular arrhythmias in patients with hypertrophic cardiomyopathy?
In a small cohort of patients with hypertrophic cardiomyopathy, the presence of late potentials on high-resolution ECG was not significantly associated with high-risk clinical markers such as familial sudden death or syncope.
Late potentials lack association with high-risk HCM features in this small series; leaves open their prognostic utility for sudden death risk stratification.
Familial hypertrophic cardiomyopathy is an autosomal dominant genetic disease considered the most common cause of sudden cardiac death in individuals under 35 years old, especially the athletes. This study aimed to investigate the association between the presence of late potentials and a family history of sudden death, syncope, and complex ventricular arrhythmias on patients with hypertrophic cardiomyopathy. A case series study was carried out from March 2001 to December 2002, including 22 patients with hypertrophic cardiomyopathy according to transthoracic echocardiogram criteria. Patients on a cardiac pacemaker, right bundle branch block, cardiac transplant, and under no possibilities to realize the exams were excluded. The results showed that asymmetric septal hypertrophy was the most common type (73%), 63% had a positive familial history of hypertrophic cardiomyopathy, 55% sudden cardiac death, and 23% syncope. Also, complex ventricular arrhythmias were detected in 14% and late potentials in 23% of patients. According to this study, the presence of late potentials was not associated with familial sudden death, syncope, and complex ventricular arrhythmias.
No takes yet. Share an insight, caveat, or question.
Chaves-Markman et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: