A disposable rapid on-chip whole blood/plasma separator has been simply implemented by packing two different sizes of silica beads at the inlet of a microchannel for application to point-of-care (POC) clinical diagnostics. Our suggested technique can be utilized to implement an integrated microfilter for a wide range of Lab-on-a-Chip (LOC) devices.
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Shim et al. (2012) studied this question.
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