There is evidence that dependence can develop to tranquillizers and that they can cause states of physical dependence similar to those obtained with barbiturates. Withdrawal manifestations are usually less severe and of shorter duration. They include agitation, restlessness, tremor, muscle twitching, insomnia, anxiety, depression and confusional states with disorientation. After high doses hallucinations, delirium and convulsions can occur.
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S. M. Hanna (1972) studied this question.
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