Y1 adrenal tumor cells exhibit resistance to the steroidogenic effects of Angiotensin II due to A-II receptors being negatively coupled to adenylate cyclase via Gi proteins and reduced coupling with phospholipase C.
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Does not alter clinical management of adrenal or hypertensive disorders; leaves open the role of Gi coupling in angiotensin II resistance in human physiology.
Bégeot et al. (1987) studied this question.
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