Why the study?
How do different sleep stages affect coronary hemodynamic function in a canine model?
Population
Chronically instrumented dogs
Comparison
Rapid eye movement sleep and slow-wave sleep… vs Awake levels
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic surges in REM sleep; leaves open relevance to human coronary events.
How do different sleep stages affect coronary hemodynamic function in a canine model?
REM sleep induces sympathetic-mediated surges in heart rate and coronary blood flow, whereas slow-wave sleep reduces coronary blood flow and increases vascular resistance in a canine model.
Kirby et al. (1989) studied this question.
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