Why the study?
Wolff-Parkinson-White syndrome has a proven genetic component, motivating a review of literature data on PRKAG2 and PRKAG3 gene variants.
Are variants in the PRKAG2 and PRKAG3 genes associated with the development of Wolff-Parkinson-White syndrome?
Are variants in the PRKAG2 and PRKAG3 genes associated with the development of Wolff-Parkinson-White syndrome?
Answers are grounded in this paper and cite their sources.
Genotyping of PRKAG2 and PRKAG3 genes may help identify the molecular etiology of WPW syndrome and provide a basis for personalized prognosis.
Wolff-Parkinson-White syndrome (WPW) is a syndrome with early ventricular excitation due to the abnormal electrical conduction through an accessory atrioventricular pathway, and is usually accompanied by supraventricular tachycardia. There is a proven genetic component in the development of this syndrome. This review presents current literature data on the association of nucleotide sequence variants of the PRKAG2 and PRKAG3 genes in patients with WPW.
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Tolstokorova et al. (2023) studied this question.
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