Caution during use of desmopressin in IPSS

We thank Dr Pecori Giraldi and colleagues for their letter concerning caution during the use of desmopressin in inferior petrosal sinus sampling (IPSS). The authors suggest that, because of the hypercoagulable state that characterizes Cushing's disease, desmopressin may not be safe since it has been shown to increase the level of von Willebrand factor and could therefore lead …