Why the study?
New-onset prediabetes/diabetes after acute pancreatitis is the most common sequela of pancreatitis and differs from type 2 prediabetes/diabetes mellitus, prompting study into associations between pancreatic enzymes and fat phenotypes.
New-onset prediabetes/diabetes after acute pancreatitis (NODAP) exhibits a distinct pathophysiological profile compared to T2DM, marked by an inverse association between pancreatic amylase and specific fat phenotypes.
BACKGROUND: New-onset prediabetes/diabetes after acute pancreatitis (NODAP) is the most common sequela of pancreatitis, and it differs from type 2 prediabetes/diabetes mellitus (T2DM). AIM: To study the associations between circulating levels of pancreatic amylase, pancreatic lipase, chymotrypsin and fat phenotypes in NODAP, T2DM, and health. METHODS: = 30) were included. Five fat phenotypes (intra-pancreatic fat, liver fat, skeletal muscle fat, visceral fat, and subcutaneous fat) were determined using the same magnetic resonance imaging protocol and scanner magnet strength for all participants. One-way analysis of covariance, linear regression analysis, and relative importance analysis were conducted. RESULTS: = 15.3% out of 41.2%). None of the phenotypes contributed meaningfully to the variance in pancreatic lipase or chymotrypsin. CONCLUSION: Both NODAP and T2DM are characterized by increased IPFD and visceral fat volume. However, only NODAP is characterized by significant inverse associations between the two fat phenotypes and pancreatic amylase.
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Ko et al. (2021) studied this question.
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