N -Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and N -Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment

This is the authors' abstract. We don't add key points for this paper.

The distribution of N -acetyltransferase 2 gene ( NAT2 ) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in the South African population is limited. We investigated NAT2 polymorphisms and their effect on isoniazid pharmacokinetics (PK) in Zulu black HIV-infected South Africans in Durban, South Africa. HIV-infected participants with culture-confirmed pulmonary tuberculosis (TB) were enrolled from two unrelated studies.