What question did this study set out to answer?

Determine whether a synthetic small-molecule drug can emulate the protective metabolic actions of adiponectin by targeting its receptors.

December 19, 2013ScienceOpen Access

Ronning After the Adiponectin Receptors

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Determine whether a synthetic small-molecule drug can emulate the protective metabolic actions of adiponectin by targeting its receptors.
Evaluated the biological activity of an adiponectin-mimetic small molecule in cell cultures.
Tested the compound in vivo using animal models presenting with diabetes and obesity.
The small-molecule drug replicated the cellular signaling and downstream beneficial actions typically triggered by natural adiponectin.
Treatment produced positive metabolic effects in diabetic and obese animal models without quantitative endpoints reported in the text.

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Implication

Preclinical investigation reveals that a small-molecule drug mimics adiponectin in cell and animal models, indicating a therapeutic target for diabetes and obesity.

Cite This Study

Holland et al. (2013) studied this question.

synapsesocial.com/papers/6a833ee834cda9cf27a6e2f3 https://doi.org/10.1126/science.1249077

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Implication

Preclinical investigation reveals that a small-molecule drug mimics adiponectin in cell and animal models, indicating a therapeutic target for diabetes and obesity.

Ronning After the Adiponectin Receptors

Key Points

Discussion

Implication

Cite This Study

Ronning After the Adiponectin Receptors

Key Points

Discussion

Implication

Cite This Study

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