Why the study?
Does propranolol alter myocardial CPK distribution space and rate of disappearance in a canine model?
Does propranolol alter myocardial CPK distribution space and rate of disappearance in a canine model?
Propranolol increases the disappearance rate of CPK, which could produce artifactual reductions in infarct size measurements if serial CPK techniques are used without accounting for this effect.
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May artifactually lower CPK-derived infarct size estimates in propranolol-treated canine models; hypothesis-generating and should not change practice.
Cairns et al. (1977) studied this question.
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