An investigation has been made into whether hemoperfusion over activated charcoal effects the rate of DNA synthesis in the rat liver undergoing compensatory hyperplasia. Hemoperfusion was performed in the unrestrained and conscious rat, thus minimizing any possible effects of stress and eliminating exposure to anesthetic agents. The results demonstrate that hemoperfusion over Norit RBX1 charcoal does not influence the liver to undergo compensatory hyperplasia following partial hepatectomy when hemoperfusion is performed immediately after hepatic injury, and that liver mass, function, and fat content consequent upon partial hepatectomy are also not influenced.
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Ryan et al. (1982) studied this question.
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