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This essay looks at the historical significance of two APS classic papers that are freely available online: Pappenheimer JR and Soto-Rivera A. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs. Am J Physiol 152: 471–491, 1948 ( http://ajplegacy.physiology.org/cgi/reprint/152/3/471 ). Pappenheimer JR, Renkin EM, and Borrero LM. Filtration, diffusion and molecular sieving through peripheral capillary membranes: a contribution to the pore theory of capillary permeability. Am J Physiol 167: 13–46, 1951 ( http://ajplegacy.physiology.org/cgi/reprint/167/1/13 ).
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C. C. Michel (2004) studied this question.
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