Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C–H and Thiols in Water for C–S Formation

Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C–S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C–H and S–H to synthesize aryl sulfides in water, utilizing CoPcS as the catalyst and O 2 as the oxidant. This protocol shows great tolerance of a wide range of substrates. A large variety of organosulfur compounds were produced in modest to excellent yields.