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A series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0.05–5.6 μM on MDA-MB-231 and 0.02–12.5 μM on PC-3.
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Görmen et al. (2010) studied this question.
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