Bile Acid Breath Test: Extremely Simple, Moderately Useful

Editorial Notes1 November 1973Bile Acid Breath Test: Extremely Simple, Moderately UsefulALAN F. HOFMANN, M.D., PAUL J. THOMAS, PH.D.ALAN F. HOFMANN, M.D.Search for more papers by this author, PAUL J. THOMAS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-743 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the widespread use of 14C-labeled compounds in clinical research, the Atomic Energy Commission's current list of "recognized medical uses of radioisotopes" does not include a single test using 14C. But the breath test for measuring bacterial deconjugation of bile acids may soon qualify as the first routine clinical diagnostic procedure using 14C. Since the test was reported 2 years ago (1, 2), three other laboratories (3, 4)* have agreed that the test can give useful diagnostic results in enterohepatic disease.The test is appealing because it is simple to do and to interpret. The procedure is noninvasive, has no...References1. FROMMHOFMANN HA: Breath test for altered bile acid metabolism. Lancet 2:621-625, 1971 CrossrefMedlineGoogle Scholar2. SHERRSASAKINEWMAN HYA: Detection of bacterial deconjugation of bile salts by a convenient breath-analysis technique. N Engl J Med 285:656-661, 1971 CrossrefMedlineGoogle Scholar3. PARKINO'MOORECUSSONS DRD: Evaluation of the "breath test" in the detection of bacterial colonisation of the upper gastrointestinal tract. Lancet 2:777-780, 1972. CrossrefMedlineGoogle Scholar4. JAMESAGNEWBOUCHIER OJI: Assessment of the 14C-glycocholic acid breath test. Br Med J 3:191-195, 1973 CrossrefMedlineGoogle Scholar5. FROMMTHOMASHOFMANN HPA: Sensitivity and specificity in tests of distal ileal function. A prospective comparison of bile acid and vitamin B12 absorption in ileal resection patients. Gastroenterology 64:268-277, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Gastroenterology Department of Medicine Mayo Clinic and Mayo Foundation Rochester, Minnesota*PEDERSON KL, ARNFRED T, HESS THAYSENN E: Rapid screening of increased bile acid deconjugation and bile acid malabsorption by means of the glycine-1-14C-cohylglycine assay. Scand J Gastroenterol. In press.†Rohm and Haas Co., Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver diseaseDFA comparison of the structure and function of the terminal lleum in crohn's disease using radiology, the “dicopac” schilling test and [14C] G.C.A. Breath testBreath TestsAppraisal of the 14C-glycocholate acid test with special reference to the measurement of faecal 14C excretionRole of bacterial overgrowth in the malabsorption syndrome of primary small intestinal lymphoma in IranBREATH-HYDROGEN TEST FOR SMALL-INTESTINAL BACTERIAL COLONISATIONDevelopment of an Intravenous Bile Acid Tolerance TestMetabolism of mevalonate in rats and man not leading to sterols.Increased Sensitivity of the Cholylglycine Breath Test for Detecting Ileal DysfunctionAssessment of Aminopyrine Metabolism in Man by Breath Analysis after Oral Administration of 14 C-AminopyrineAcquired Hyperoxaluria, Urolithiasis, and Intestinal Disease: A New Digestive Disorder? 1 November 1973Volume 79, Issue 5Page: 743-744KeywordsBileGastroenterology and hepatology ePublished: 1 December 2008 Issue Published: 1 November 1973 PDF downloadLoading ...