A range of 14-esters (8 approximately 13) of the title compound, 3'-deamino-3'-hydroxydoxorubicin 3',4'-diacetate (5), has been synthesized by nucleophilic substitution of the corresponding 14-bromide (6) by the appropriate sodium carboxylate salts. Antitumor activities were determined in vivo in the murine P388 lymphocytic leukemia assay and compared with those of the 14-hydroxy and 14-acetoxy analogs.
No takes yet. Share an insight, caveat, or question.
Horton et al. (1983) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: