Response to Drug Stimulation Method. Specimens of muscle both longitudinal and transverse were removed at operation from the agan- glionic segment of bowel of patients with Hirschsprung's disease and from similar regions of the pelvi-rectal junction and upper rectum from patients with miscel- laneous conditions. The mucous membrane was removed and strips of muscle were suspended in oxy- genated tyrode at 37C. The contractions of the muscle were recorded by a lever writing on a smoked drum.
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Trounce et al. (1960) studied this question.
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