Summary. By means of density gradient centrifugation the catechol amine granules in the cow adrenal medulla have been isolated free or practically free from mitochondria and microsomal material. The isolated granules have a very high content of pressor amines (about 35 μ moles/mg protein‐N). The soluble protein fraction that is released together with the amines at osinoticlysis of the granules, represents the main part (77 per cent) of the total granule proteins. The granules show a high ATPase activity and probably contain an adenylate kinase.
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Nils‐Åke Hillarp (1958) studied this question.