Why the study?
Large, mobile LAA thrombus carries an urgent risk of systemic embolization, but management is challenging when anticoagulation or open surgery is unsuitable in elderly or frail patients.
Robot-assisted minimally invasive surgery provides a safe and definitive alternative for en bloc removal of large, mobile LAA thrombi and LAA closure in frail patients unsuitable for conventional therapies.
May support percutaneous options for LAA thrombus in frail patients unsuitable for standard therapies; hypothesis-generating and requires prospective validation.
BACKGROUND: Large, mobile thrombus in the left atrial appendage (LAA) carries an urgent risk of systemic embolization. Management is challenging when anticoagulation or open surgery is unsuitable in elderly or frail patients. CASE SUMMARY: A 78-year-old woman with prior atrial fibrillation ablation was detected a large mobile LAA thrombus on surveillance imaging after self-discontinuing apixaban. Anticoagulation and systemic thrombolysis carried a high embolic risk, open surgery was unsuitable due to age and frailty, and percutaneous closure was contraindicated. Urgent robot-assisted en bloc thrombectomy with internal LAA closure via right mini-thoracotomy achieved complete exclusion. She was discharged on postoperative day 5 without complications. DISCUSSION: Robot-assisted cardiac surgery enables definitive thrombus removal and secure LAA closure in selected high-risk patients, offering a minimally invasive alternative to sternotomy. TAKE-HOME MESSAGE: In elderly, frail patients with large, mobile LAA thrombus, robot-assisted minimally invasive surgery is a safe, effective alternative when conventional strategies are unsuitable.
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Otake et al. (2025) studied this question.
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