Why the study?
Does the choice of opioid and lockout interval influence PCA use patterns and pain relief in women following gynecological surgery?
Does the choice of opioid and lockout interval influence PCA use patterns and pain relief in women following gynecological surgery?
Fentanyl and morphine provide equivalent pain relief via PCA after gynecological surgery, though fentanyl may initially improve the demand/delivery ratio.
Answers are grounded in this paper and cite their sources.
Supports equivalent fentanyl or morphine PCA after gynecological surgery; confirms lockout interval flexibility without outcome impact.
This study systematically compared 2 opioids, morphine (MOR) and fentanyl (FEN), and 2 lockout intervals, long (L) and short (S) in patients utilizing patient-controlled analgesia (PCA). Seventy-eight women undergoing gynecological surgery were randomly assigned to 1 of 4 groups: MOR-S (7 min), MOR-L (11 min), FEN-S (5 min), FEN-L (8 min). PCA measures obtained during the first 24 h after surgery included: number of demands/h, number of completed deliveries/h, dose/h, and demand/delivery ratio. Visual analog scales of pain and anxiety were also obtained. Results indicated that pain relief was equivalent with minimal side effects for both opioids. The selection of opioid, however, influenced the pattern of PCA use, with an improved demand/delivery ratio initially for FEN. The lockout intervals chosen for this study did not influence pain or anxiety levels.
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Ginsberg et al. (1995) studied this question.
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