Why the study?
Initial findings suggested lower MACE rates with noncoronary sinus pivot implantation during TAVR for pure native aortic regurgitation, prompting a comparison between this strategy and conventional approaches.
Does the noncoronary sinus pivot implantation (NCPI) strategy improve device success and reduce complications compared to the conventional approach in patients undergoing TAVR for pure native aortic regurgitation?
Does the noncoronary sinus pivot implantation (NCPI) strategy improve device success and reduce complications compared to the conventional approach in patients undergoing TAVR for pure native aortic regurgitation?
Answers are grounded in this paper and cite their sources.
The noncoronary sinus pivot implantation (NCPI) strategy significantly improves device success and reduces short-term complications in patients undergoing TAVR with self-expanding valves for pure native aortic regurgitation.
BACKGROUND: Our initial study suggested that patients undergoing transcatheter aortic valve replacement (TAVR) with a self-expanding valve for pure native aortic regurgitation (PNAR) had a lower rate of major adverse cardiac events (MACE) when the noncoronary sinus pivot implantation (NCPI) was achieved. OBJECTIVES: This study enrolled patients with PNAR who underwent TAVR with self-expanding valves between January 2019 and April 2024, compared the NCPI strategy with the conventional approach, and analyzed factors associated with successful NCPI. METHODS: We divided 87 patients into an early (conventional) group of patients treated before February 2023 and a late (NCPI strategy) group of patients treated after February 2023. Then the patients were also categorized by successful NCPI and non-NCPI group. RESULTS: The late group had significantly higher device success rates than the early group (92.9% vs 73.3%; P = 0.016) and lower rates of MACE (19.5% vs 51.1%; P = 0.002) and valve-in-valve implantation (4.8% vs 24.4%; P = 0.01). Importantly, NCPI was achieved in 90.5% of patients in the late group compared with only 17.8% in the early group (P < 0.001). The NCPI group had a higher device success rate (93.5% vs 70.7%; P = 0.005) and lower MACE rate (17.4%vs 56.1%; P < 0.001) than the non-NCPI group. NCPI (OR: 6.71; P = 0.032) and aortic angulation (OR: 1.07; P = 0.035) were independent predictors of device success. CONCLUSIONS: NCPI strategy could be a general method used in TAVR with a self-expanding valve for patients with PNAR, which had a higher device success rate and lower rate of complications than the conventional method.
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Yang et al. (2025) studied this question.
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