Sensitization to Duck-Embryo Rabies Vaccine Produced by Prior Yellow-Fever Vaccination

RABIES vaccine derived from virus grown on Central-nervous-system tissue stimulates antibody formation against brain tissue as well as rabies. The resultant danger of inducing an isoallergic encephalomyelitis precluded utilization of such a vaccine in pre-exposure rabies prophylaxis. Since the development of avianized vaccines of chick-embryo and duck-embryo origin have practically eliminated the hazard of serious neurologic reactions1 pre-exposure vaccination has been proposed for persons encountering a substantial risk of rabies.2 , 3 Because of assignments to areas where rabies is highly endemic it is Peace Corps policy to immunize those being trained with rabies vaccine (duck embryo) before overseas departure.4 Kaiser et . . .