Three patients with abnormal thymus glands characterized principally by the absence of Hassall's corpuscles were presented. These patients do not clinically fall into either the ataxia-telangiectasia syndrome or the Swiss-type of agammaglobulinemia. This suggests that hypoplasia of the epithelial thymus, i.e., absence of Hassall's corpuscles, may be associated with a spectrum of lymphoid tissue histopatholgy and immunologic derangement, perhaps dependent on an additional lympho-immune primer. The immunologic disorders appear to have resulted in bizarre, widely disseminated lethal measles infections in each case.
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Lipsey et al. (1967) studied this question.