Active and passive smoking in married couples: results of 25 year follow up.

Electrocardiographs after overdose of tricyclic antidepressants: (a) 2 2 hours after ingestion (pulse 50 beats/min); (b) 4 hours after ingestion (pulse 104 beats/min, systolic blood pressure 75 mm Hg); and (c) 5 hours after ingestion (pulse 150 beats/min, systolic blood pressure 75 mm Hg).of atropine 0 3 mg intravenously was ineffective.She was given 10", mannitol 10 ml for any cerebral oedema and activated charcoal via the nasogastric tube.One hour later blood gas results showed correction of her acidosis (pH 7 5, carbon dioxide partial pressure 3-5 kPa (26-3 mm Hg), oxygen partial pressure 20 kPa (150 mm Hg), base excess -1-5 mmol/l, and bicarbonate 23 mmol/l).Shortly after this her pulse suddenly returned to 104 beats/min, and her blood pressure was 75 mm Hg systolic.Her electrocardiogram still showed widened QRS complexes (figure (b)), but there was a gradual improvement over the next few hours with narrowing of the QRS complexes, some ST depression, and ventricular ectopic beats (figure (c)).Ventilation was continued to maintain her respiratory alkalosis, and her electrocardiogram was monitored.Ten hours after ingestion of the tablets she responded to pain and showed some spontaneous limb movements.She was extubated after 48 hours and made an uneventful recovery.There were no residual symptoms or signs three months later.'Doll R, Gray R, Hafner B, Peto R. Mortality in relation to smoking: 22 years' observation in female British doctors.Br Med3J 1980;i:967-71.2Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study in Japan, Br MedJ7 1981;282:183-5.