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A silent mutant of the β chain of the baboon (Papio cynocephalus) was detected by high performance liquid chromatography of the globin chains. The substitution is β13 Ala → Thr. The inclusion of nonylamine in the developers for HPLC results not only in an improved separation of baboon globin chains but also in the complete resolution of the human Gγ, Aγ, and AγT chains and some common human variant β chains.
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Shelton et al. (1982) studied this question.
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