February 8, 2013Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

MicroRNA-145 Restores Contractile Vascular Smooth Muscle Phenotype and Coronary Collateral Growth in the Metabolic Syndrome

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Why the study?

Does miR-145 delivery restore coronary collateral growth in a metabolic syndrome rat model?

Structured PICO

Does miR-145 delivery restore coronary collateral growth in a metabolic syndrome rat model?

Population

JCR rats (metabolic syndrome model) and SD rats (normal model) undergoing transient, repetitive left anterior descending artery occlusion to stimulate coronary collateral growth

Intervention

miR-145 delivered via adenoviral vector (miR-145-Adv) on days 6 to 9 of coronary collateral growth stimulation

Comparator

Untreated JCR rats and normal SD rats

Outcome

Coronary collateral growth evaluated by coronary blood flow measurements (collateral/normal zone flow ratio) at 9 dayssurrogate

Restoration of miR-145 levels in a metabolic syndrome rat model successfully restores vascular smooth muscle cell contractile phenotype and coronary collateral growth.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports miR-145 as a target for collateral restoration in metabolic syndrome; hypothesis-generating and requires human validation.

Cite This Study

Hutcheson et al. (2013) studied this question.

synapsesocial.com/papers/6a8382ba3965fa42e1c94e54 https://doi.org/10.1161/atvbaha.112.301116

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