Variable ventilation from bench to bedside
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Why the study?
Does variable mechanical ventilation improve gas exchange and lung mechanics compared to conventional mechanical ventilation in experimental models of ARDS and healthy lungs?
Population
Experimental animal models of acute respiratory distress syndrome induced by various methods and healthy…
Comparison
Variable controlled mechanical ventilation and… vs Conventional controlled mechanical ventilation…
Design
Review
Authors
Discussion
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Implication
Variable ventilation merits clinical trials in ARDS; leaves open translation from experimental models.
Structured PICO
Does variable mechanical ventilation improve gas exchange and lung mechanics compared to conventional mechanical ventilation in experimental models of ARDS and healthy lungs?
P
Population
Experimental animal models (including pigs, guinea pigs, dogs, lambs, and rodents) of acute respiratory distress syndrome (ARDS) induced by various methods (surfactant depletion, oleic acid, HCl aspiration) and healthy lungs.
I
Intervention
Variable controlled mechanical ventilation and variable pressure-support ventilation (PSV) with external variation of tidal volume and/or respiratory rate.
C
Comparator
Conventional (monotonic/regular) controlled mechanical ventilation and conventional PSV.
O
Outcome
Gas exchange (arterial oxygenation, PaCO2) and lung mechanics (respiratory system compliance and resistance).surrogate
In experimental models, variable mechanical ventilation generally improves gas exchange and lung mechanics compared to conventional ventilation by enhancing recruitment and ventilation-perfusion matching.
Limitations
- Experimental ARDS models do not reproduce all features of human ARDS
- Degrees of recruitability, tissue damage, and inflammation differ widely among experimental models
Cite This Study
Huhle et al. (2016) studied this question.
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